Systematic Literature Search & Screening

# Systematic Literature Search & Screening

Systematic literature reviews are the foundation of evidence-based pharmaceutical decision-making. AI transforms the most time-consuming phases.

Search Strategy Development

Help me develop a systematic search strategy for:

Research question: What is the efficacy and safety of [drug/intervention]
compared to [comparator] for [condition] in [population]?

PICO framework:
- Population: [specific patient population, age, disease stage]
- Intervention: [drug, dose, route, duration]
- Comparator: [placebo, active comparator, standard of care]
- Outcomes: Primary: [efficacy endpoint]
              Secondary: [safety endpoints, QoL, biomarkers]

Develop search strategies for:
1. PubMed/MEDLINE
   - MeSH terms and free-text keywords
   - Boolean operators and search string
   - Limits (date range, study type, language)

2. Embase
   - Emtree terms + free-text
   - Adaptations from MEDLINE strategy